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PLRG Injection

General Information

PLRG stands for percutaneous leukocyte-rich or platelet-rich gel. The injection procedure is similar to a platelet rich plasma injection. Percutaneous means under the skin. Platelet gel is a relatively new technology used in the healing of wounds and bone and joint injuries. The use of PLRG in injected therapies encourages focused treatment through the presence of proteins called growth factors, which help speed up the healing process and encourage tissue regeneration.

In many situations, PLRG is an injection treatment combines with other orthopedic repair procedures such as rotator cuff repair or knee surgery to facilitate healing of bones and connective tissues found in the joint.

The PLRG procedure is used mainly to encourage union between bones at fracture sites, or to encourage healing when non-union in bone fractures occurs.

Reasons for PLRG

  • Joint injuries
  • Knee surgery
  • Increase healing time
  • Increase range of motion


Your doctor will take complete physical history from you and give you a thorough physical examination to make sure you're a good candidate for PLRG. He may also order a number of tests, including:

  • Nerve conduction studies
  • EMG - electromyogram studies • Musculoskeletal ultrasound
  • Gait studies and analysis
  • X-rays
  • MRI

PLRG Injection Procedure

The PLRG injection procedure takes place in your doctor's office.

  • Blood is drawn from your arm
  • Platelet plasma is separated from other blood components in a centrifuge machine to create a solution often called a gel or platelet rich plasma
  • The platelet gel/plasma is drawn into a syringe
  • The injection site is prepared and anesthetized
  • The platelet gel/plasma is injected directly into the tendon or area to be treated

What to Expect

The PLRG injection procedure has been determined to be less invasive than bone marrow injections and open surgical grafting techniques.

Upon your doctor's instruction, you will engage in physical or rehabilitation therapy in order to facilitate strengthening, stretching and stability of the affected area. You may be restricted from playing sports for up to 12 weeks following the injection, with activities gradually added to your lifestyle.